We all know that without experimental animals, global medicine would not be so advanced. Various known and unknown viruses and bacteria have attacked the earth on a large and small scale one after another. Scientists all over the world are trying to develop symptoms through various experiments. The way of treatment, so the clean functional places such as laboratory animal rooms have developed faster and larger in recent years. CEIDI Xidi, which specializes in the overall solution of clean engineering, will come to the popular science laboratory animal room this time for some relevant knowledge for relevant enterprises to understand and learn.

1. Pathological examination standards for four types of laboratory animals

In the pathological examination, the four types of experimental animals also have different pathological examination standards.

Level 1: Healthy appearance, no lesions on major organs.

Class 2: Except for the first-level indicators, there are no lesions with second-level microbial pathogens under microscope.

Level 3: Animals without special pathogens. No secondary or tertiary microbial pathogens.

Grade 4: Lesions that do not contain secondary and tertiary microbial pathogens. The spleen and lymph nodes are histological structures of sterile animals.

2. Laboratory animal microorganism control standards

Experimental animals can be divided into four levels, which are ordinary animals, clean animals, animals without special pathogens, and sterile or full-bodied animals.

① First-level common animals: First-level common animals (CV), laboratory animals that do not carry pathogens of zoonotic diseases and severe animal infectious diseases. The feeding environment is an open system, and there is no requirement for air cleanliness.

②Secondary clean animals: Class II clean animals (CL), except for pathogens that should be excluded from ordinary animals, do not carry pathogens that are harmful to animals and interfere with scientific research. From SPF animals or Caesarean section animals. Generally raised in a semi-barrier system.

③The third-level special pathogen-free animal: The third-level special pathogen-free animal (SPF) refers to the animal without specific microorganisms and parasites in the animal, but with non-specific microorganisms and parasites. Mainly refers to the pathogens that do not carry potential infections, conditional diseases, and interfere with the experiment. It is derived from animals delivered by caesarean section and raised in the barrier system.

④Grade four sterile animals (GF) or GN animals: GF or GN animals. Sterile animals refer to any part of the animal's body and outside using existing detection technology. Animals with no live microorganisms and parasites can be detected. Sterile animals originate from caesarean section or hatching of sterile eggs and are raised in an isolation system. Known animals or known bacteria animals, in a broad sense, sterile animals, known bacteria animals, and animals without specific pathogens are collectively called known animals; in a narrow sense, they refer to known bacteria animals.

3. Requirements for the design and management of animal laboratories

There are different requirements for the design and management of animal laboratories for different levels of laboratory animals. Sterile, known bacteria and animals without special pathogens need to be raised in a sterile or as sterile environment as possible. This environment is currently commonly referred to as a barrier environment in the world, that is, a barrier is used to pollute the animal from the surrounding environment Separated, as if the fetus was in the mother's womb. This environment can be divided into five categories from the perspective of controlling microorganisms: barrier system, open system, isolation system, laminar flow rack system and semi-barrier system.

① 　Barrier system: use a sterile clean room of about 10,000 to 100,000 as a breeding room, which is mainly used for long-term breeding and reproduction of animals without special pathogens. Strict management is implemented for entering the room, such as showering and changing of personal clothes.

②Open system: It is a system that does not eliminate pollution for people, objects, air, etc. entering and leaving the room, but usually requires a certain degree of cleaning management.

③Isolation system: It is a system that raises animals in a container with operating gloves, and is used to raise sterile animals and sedans. The interior maintains the cleanliness of class 100 according to the requirements of microorganisms, but the rooms and operators do not need to be considered as sterile rooms.

④Laminar flow rack system: The cage is placed in clean horizontal laminar air. It is often used for small-scale breeding, but there is a risk of contamination during breeding, operation and treatment in general rooms. Can be used to supplement the semi-barrier. 

⑤Semi-barrier system: relax the management of people and objects in the barrier system when entering and leaving the room, and the plane composition is roughly the same as that of the barrier system.

In summary, only contractors who have a clear understanding of the type of laboratory, rich design and construction experience and complete qualifications can build a laboratory that meets the standards. Shanghai Xidi Industrial Co., Ltd. is headquartered on the 3rd floor of Building C, Wantong Center, Hongqiao Business District, Shanghai. The company has a registered capital of 50 million. It has Grade B qualification for design, Grade 3 qualification for general contracting of construction and construction, Grade 2 qualification for decoration, electrical and mechanical installation Three-level qualification, first-level purification qualification, three-level qualification for environmental protection and steel structure. The main business scope of CEIDI Xidi is: laboratory EPC engineering, clean room EPC engineering, animal room EPC engineering. The company has always adhered to the mission and responsibility of high-level solutions, high-standard engineering quality and high-quality customer service, attaches importance to the company's brand image and sustainable development, and strives to create a "safe, standardized and comfortable" experimental production environment is its consistent pursuit. As of 2020, CEIDI Xidi has built benchmark projects for more than 1,000 companies in the fields of laboratories, clean rooms, animal rooms, and operating rooms, with a cumulative construction area of more than 2 million square meters.